Abstract
Method: Each patient was studied in detail with relevant clinical history and examination with following various investigations like peripheral smear for malarial parasite, complete blood count, renal function test, liver function test, blood sugar level, USG abdomen, chest x-ray, urine routine and micro and some special investigations like arterial blood gas analysis, bleeding profile, G6PD activity.
 Result: Out of all patients 64% (32) had hemoglobin less than 10 g/dl. Amongst all patients with malaria 18 cases of P.vivax, 8 cases of P.vivax and 6 patient mixed infection had anemia with Hb<6g/dl. In terms of percentage 57.14% of P.falciparum and 60% of P.vivax had anemia Lowest Hemoglobin was 2.1mg/dl noted with patient of mixed infection. It was managed with transfusion of packed cell volume.
 Conclusion: Both species are commonly presented with symptoms of intermittent Fever, chills, Bi-frontal headache, vomiting and commonly clinical feature is splenomegaly. Severe complication like anemia, thrombocytopenia jaundice, acute renal failure and sometimes life threatening cerebral malaria are need to address promptly to avoid adverse outcome. All severe complications can be found in bothspecies, though less common in P.vivax as compared to Plasmodium falciparum.
 Keywords: Complication, Malaria, diagnosis & Clinical Presentations
Highlights
Malaria is one of the major public health problems in India
All severe complications can be found in bothspecies, though less common in P.vivax as compared to Keywords: Complication, Malaria, diagnosis & Clinical Presentations
S.bilirubin of > 3 mg/dl was seen in 23 (46%)patients with complicated malaria, in which 40% patients had complicated P.vivax malaria while in complicated P.falciparum it was raised in 50% patient which shows that complications related to hepatic injury are more in P.falciparum than in P.vivax
Summary
Around 1.5 million confirmed cases are reported annually by National Vector Born Disease Control Programme. The plasmodium parasites are very specific with man as the only intermediate specific vertebrate host and female Anopheles mosquitoes as the vector and definitive host. There has been increasing trend in the past few years for reporting various atypical clinical manifestations and complications of malaria.[2]. Cerebral malaria is the leading cause of death in malaria accounting for 80% of malaria mortality. Coma persisting for more than 30 minutes after generalised convulsions is a feature of cerebral malaria. It is estimatedthat between 0.8% to 1.5% of all patients with P.falciparum infection progress to cerebral malaria.[3]
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