TO STUDY CLINICAL SIGNIFICANCE OF RETICULOCYTE HAEMOGLOBIN CONTENT IN IRON DEFICIENCY ANEMIA

Abstract

Background- Anemia is foremost health problem worldwide that need total elimination according to United Nation declaration 1997. Approximately 2 billion population suffer from iron deciency or anemia globally Worldwide (IDA) is the commonest form of nutritional anemia. 1 2 Various biochemical markers used for diagnosis of Iron deciency anemia are MCV, ferritin, transferrin saturation (TS) and serum iron . CHr 3 indicates availability of Iron for haemoglobin production in the bone marrow. Therefore, CHr has been proposed as marker of iron status in body 4 Several studies indicated that CHr measurement useful for IDA and reliable marker for monitoring iron therapy's efcacy and iron status in body. 5,6 7 that's why we needed this study to know the role of CHr in IDA. Our objectives were to evaluate the level of reticulocyte haemoglobin content in the diagnosis and treatment of iron deciency anemia Materials and Methods – A hospital based prospective study was undertaken at our tertiary care centre in the department of General Medicine, MGMs Medical College & Hospital Aurangabad on admitted patient , of patients with newly diagnosed and untreated Iron Deciency Anemia (mild-moderate) according to WHO criteria conrmed by iron studies were included. Results – In the study total 96 patients included amongst them 63.5 % were females and majority patients (35.5 %) were in the age group of 31-40 years. Reticulocyte Haemoglobin (CHr) showed a signicant positive correlation with haemoglobin (r=0.782; ), MCV (r=0.871; ), p<0.05 p<0.05 MCHC (r=0.685; ), MCH (r=0.879; ), serum iron (r=0.651; ), and % Saturation (r=0.702; ). CHr showed p<0.05 p<0.05 p<0.05 p<0.05 signicant negative correlation with TIBC (r=-0.613; ) and Ferritin (r=-0.604; ). p<0.05 p<0.05 Conclusion – CHr is a useful parameter that can be condently used in the diagnosis of Iron deciency anemia (IDA) and a CHr cut-off value predicts IDA. Ferric carboxymaltose was usually well tolerated and had a good impact in the management of iron-deciency anemia. After iron replacement therapy CHr values increased correlated with haemoglobin and iron level. We cannot replace iron study but CHr can be used for early diagnosis of Iron deciency anemia and in management of iron deciency.