Abstract
Synapse formation is a complex process requiring a high degree of coordination between presynaptic and postsynaptic cells. Speed and reliability of synaptic transmission demand that the appropriate neurotransmitter receptors be highly concentrated in the postsynaptic membrane precisely beneath transmitter release sites in the presynaptic cell. In the central nervous system, a single neuron may receive thousands of synaptic contacts from other neurons releasing a variety of neurotransmitters. Thus, neurons must possess the ability not only to cluster, but also to sort, the proper transmitter receptors to the correct synaptic site. Understanding, on a molecular level, how such specializations develop is a major goal of neurobiological research. This commentary will focus on the synaptic clustering and anchoring of neurotransmitter receptors through their association with a variety of cytoplasmic proteins.
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