TO KNOW THE ASSOCIATION OF PLATELET ACTIVITY ON GLYCEMIC STATUS AND VASCULAR COMPLICATIONS IN DIABETES MELLITUS

Abstract

Background: Diabetes mellitus is a global pandemic disease. Hyperglycemia contributes to greater platelet reactivity through direct effects and by promoting glycation of proteins. Mean platelet volume(MPV) and Mean platelet count(MPC) is an indicator of average size and activity of the platelets and is high in diabetes mellitus. Objectives: 1) To nd the association between MPC and MPVwith HBA1C in diabetic patients. 2) To nd the association of MPC and MPV with vascular complications in diabetic patients. Methodology: A retrospective study conducted in the Department of Pathology from January 2021 to June 2021. Data was collected from backbone stored in digital form. Sample size : 92 diabetic patients and are divided into 2 groups. 1) Group 1: HbA1c <7. 2) Group 2: HbA1C ≥7. Platelet count, MPV, HbA1c values and vascular complications were analyzed. Results: Out of 92 diabetic patients 74 had vascular complications. MPC in group 1 and group 2 was found to be 231.727 and 312.346 respectively with signicant p value of 0.036 and mean difference of -80.6184. MPV in group 1 and group 2 was found to be 10.200 and 9.999 respectively which showed no signicant correlation with p value of 0.528 and mean difference of 0.2012. The MPC and MPV in diabetic patients with complications were 332.056 and 10.239 respectively showing no signicant correlation. Conclusion: MPC and MPV were found to be raised in group 2. MPC between the 2 groups showed statiscally signicant difference. However MPV does not show any signicance between the two groups. Though there was no signicant difference between Platelet count and vascular complication, MPVwas higher in patients with complications. Diabetic patients suffer mostly from vascular complications, therefore platelet count and HbA1c can be a useful prognostic marker of vascular complications in diabetics.