To Investigate the Associations of Dyslipidemia and BMI, as Risk Factors Leading to Insulin Resistance and Development of Type2 Diabetes Mellitus in Baqubah City

Abstract

Insulin resistance is a condition in which persons with type 2 diabetes make insulin but is unable to use it properly to transfer glucose into cells, resulting in high blood glucose levels. Obesity, particularly visceral fat (fat surrounding the organs) is a major cause of insulin resistance. The homeostasis model evaluation is the gold standard method for determining whether or not a person is insulin resistant. This article tries to investigate the development of the values of some parameters among type 2- diabetic patients versus normal levels of healthy control groups these parameters included FBS, HbAIc (%), FIL, HOMAIR age BMI and lipid profile. The results found that the means values of FBS(mg/dl), HbAIc (%), FIL (miu /L), HOMAIR were (175.96± 39.68, 9.74±1.82 , 18.99±5.98 , 8.136±2.53) respectively versus normal levels of control group (85.44±7.58, 4.92±.500 , 5.79 ± 0.5, 1.22±0.17). While means of age and BMI (kg/m²) of cases were (54.27±13.35, 32.20±2.23) versus the mean for the control group (47.12±10.77, 26.04±1.65) respectively. The levels of total cholesterol (mg/dl), triglycerides (mg/dl), LDL (mg/dl) and VLDL (mg/dl) among type-2 diabetic patients were(238.19±8.27, 183.48±7.66, 117.20±8.59, 36.69±4.28) respectively versus normal concentrations among control groups with mean values (146.03±7.48, 137.54±7.43, 87.55±6.92, 23.6±5.58) respectively, While the mean value of HDL-C was (40.34±9.82) in patients and (52.31± 4.94) in control. In all these parameters there were highly significant differences between case and control (with (p-value= >0.001) and the mean values of patients with type 2 DM were more than control except the values of HDL-C were in patients less than in control. This study found that the results of the tests FBS, HbAIc (%), age BMI and lipid profile in patients with diabetes type 2 in comparison to the control group have a significant correlation with FIL, HOMAIR.