TO FIND RELATIONSHIP BETWEEN COLONIC MUCOSAL CHANGES IN PATIENTS OF LIVER CIRRHOSIS WITH PORTAL HYPERTENSION.

Ankit Meshram,Dr Prashanth P N

doi:10.32553/ijmbs.v3i2.116

Abstract

Background: The aim of the study is to find relationship between Colonic Mucosal changes in patients of Liver Cirrhosis with Portal Hypertension conducted at MGM Medical College & M. Y. Hospital, Indore for one year. Result: The commonest symptom in patients was abdominal distension 30 (100%), next common was jaundice 20 (66.7%), malena 17 (56.7%), hemetemesis 10(33.3%), hematochezia 10(33.3%), and pruritis 2(6.6%) was noted. It is evident from table no .13 that out of 30 patients , serum prothrombin time was prolonged in 30 (100%) patients ,serum albumin was decreased in 20 (66.7%) patients , platelet count was decreased in 16 (53.3%) , serum bilirubin was raised in 14 (46.7%) patients , SGOT/SGPT was raised in 17 (56.7%) patients. Conclusion: Our study states that most of the changes which we found on colonoscopic studies were similar to other studies. The only finding which we got in excess in comparison to other studies was colitis like abnormality which was 73.3% which may be probably due to chronic intestinal infections which occur in our country. Keywords: Colonic Mucosal, Liver Cirrhosis, Portal, Hypertension.

Highlights

Cirrhosis is a pathologically defined entity that is associated with a spectrum of characteristic clinical manifestations
The study was carried out on 30 patients of liver cirrhosis with portal hypertension, both from inpatients admitted in medicine wards and outpatients attending medicine OPD and gastroenterology OPD at MGM Medical College & M
It is evident from table no .13 that out of 30 patients, serum prothrombin time was prolonged in 30 (100%) patients,serum albumin was decreased in 20 (66.7%) patients, platelet count was decreased in 16 (53.3%), serum bilirubin was raised in 14 (46.7%) patients, SGOT/SGPT was raised in 17 (56.7%) patients

Summary

Introduction

Cirrhosis is a pathologically defined entity that is associated with a spectrum of characteristic clinical manifestations. The cardinal pathological features reflect irreversible chronic injury of the hepatic parenchyma and include extensive fibrosis In association with the formation of regenerative nodules. These features result from hepatocyte necrosis, collapse of the supporting reticulin network with subsequent connective tissue deposition, distortion of the vascular bed, and nodular regeneration of remaining liver parenchyma [1]. The aim of the study is to find relationship between Colonic Mucosal changes in patients of Liver Cirrhosis with Portal Hypertension conducted at MGM Medical College & M. Result: The commonest symptom in patients was abdominal distension 30 (100%), common was jaundice 20 (66.7%), malena 17 (56.7%), hemetemesis 10(33.3%), hematochezia 10(33.3%), and pruritis 2(6.6%) was noted.

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