Abstract
Background: Carcinoma cervix ranks fourth most common malignancy (for both incidence & mortality) globally and third most common diagnosed malignancy in females (~16.5%) in India, (after breast & lip/oral cavity), with about 80% of the total burden occurring in developing countries like India.
 Methods: This Prospective comparative study was conducted in the Department of Radiotherapy and Oncology TCC, IGMC, Shimla, in patients suffering from
 advanced carcinoma of cervix.
 Results: Hematological toxicities were seen mainly in the study group as compared to the control group (28 patients in the study group vs. 22 patients in control group). The difference was not statistically significant (p = 0.214). Grade III toxicities were seen in 5 patients in study group and 4 patients in control group. Cutaneous toxicity of different grades was seen in all the patients in the study arm and of the patients in the control arm. There was no statistically significant difference between the two arms (p=0.8121).
 Conclusion: Both (Study & control) groups are comparable in terms of toxicity and are equally well tolerated by the patients.
 Keywords: Chemoradiotherapy, RT, Partial response, toxicity.
Highlights
Carcinoma cervix ranks fourth most common malignancy globally and third most common diagnosed malignancy in females (~16.5%) in India, with about 80% of the total burden occurring in developing countries like India.[1]In recent times the most significant development in the treatment of carcinoma cervix has been the introduction of chemo therapy to Radiotherapy
This Prospective comparative study was conducted in the Department of Radiotherapy and Oncology TCC, IGMC, Shimla, in patients suffering from advanced carcinoma of cervix
Grade III toxicities were seen in 5 patients in study group and 4 patients in control group
Summary
In recent times the most significant development in the treatment of carcinoma cervix has been the introduction of chemo therapy (based on cisplatin) to Radiotherapy. Chemotherapy used concomitantly with radiotherapy (CRT) has been investigated in many studies which have shown significant benefits in both survival and disease control. Methods: This Prospective comparative study was conducted in the Department of Radiotherapy and Oncology TCC, IGMC, Shimla, in patients suffering from advanced carcinoma of cervix. Grade III toxicities were seen in 5 patients in study group and 4 patients in control group. Cutaneous toxicity of different grades was seen in all the patients in the study arm and of the patients in the control arm. Conclusion: Both (Study & control) groups are comparable in terms of toxicity and are well tolerated by the patients.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
