Abstract
目的 探讨肌钙蛋白T(cTnT)在病毒性心肌炎(VMC)的诊断及病情观察方面的价值.方法对102例急性病毒性心肌炎患者进行入院后1、2、3周及3个月cTnT和心肌酶谱的动态研究;cTnT阳性率与心内膜心肌活检(EMB)病理检查诊断率的对照研究; cTnT与心电图(ECG)、及病程关系的研究.结果急性病毒性心肌炎患者在各检测期内血清cTnT的阳性率(45.1%,)较心肌酶谱各项目[肌酸激酶(CK)29.4%、肌酸激酶同工酶(CK-MB)34.3%、门冬氨酸氨基转移酶(AST)10.9%、乳酸脱氢酶(LDH)13.7%、α-羟丁酸脱氢酶(α-HBDH)12.8%]显著增高(P 0.05);cTnT阳性组ECG正常率(8.7%,4/46)明显低于阴性组(25%,14/56)(P<0.05);cTnT阳性组3个月的总治愈率(65.2%,30/46)明显低于阴性组(89.3%,50/56)(P<0.005).结论在病毒性心肌炎的诊断中cTnT可取代传统的心肌酶谱测定;cTnT具有与心内膜心肌活检同样重要的诊断价值;cTnT在病毒性心肌炎病情观察中也具有重要意义。
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