To Explore the Mechanism of Buyang Huanwu Tang in the Treatment of Hypertension Based on Network Pharmacology

Abstract

Background: Hypertension is a cardiovascular disease with high incidence. Syndrome of qi stagnation and blood stasis is a common symptom of traditional Chinese medicine in hypertension, manifested as dizziness, palpitation, chest tightness and so on. Buyang Huanwu Tang has the effect of activating blood circulation and regulating collaterals, removing blood stasis and regulating qi, which is widely used in clinical treatment of hypertension. Compared with Western medicine, Chinese medicine has different antihypertensive targets in the treatment of diseases, which can play a better antihypertensive effect. Purpose: To explore the molecular mechanism of buyang huanwu tang in the treatment of hypertension based on network pharmacology. Methods: the active components of buyang huanwu decoction were screened by TCMSP database. Prediction of relevant targets by Drugbank, GeneCards and OMIM databases; The PPI network control chart was constructed by using Cytoscape3.6.0 software. Enrichment analysis of GO and KEGG was carried out through DAVID database, and mapping was carried out by using Cytoscape. Results: a total of 97 active components, 34 disease targets and 59 pathways were screened. Conclusion: buyang huanwu decoction has the characteristics of multi-component, multi-target and multi-pathway in the treatment of hypertension. This study provides an idea for further research on the effect and mechanism of buyang huanwu decoction in the treatment of hypertension.