Abstract
Background: Post acne scarring is a consequence of abnormal resolution or wound healing following the damage that occurs in the sebaceous follicle during acne inflammation
 Methods: Interventional split face comparative prospective study was conduct at Department of Dermatology, Venereology and Leprology, S N Medical College and Attached Hospitals, Jodhpur.
 Results: After one month of 3rd treatment session, 84% patients stated that they were satisfied or very satisfied on the platelet-rich plasma side, while 7% patients stated this about the normal saline side (P = 0.18).The platelet-rich plasma side was found to have a better response than the control side and participants were more satisfied with the platelet-rich plasma side than the control side.
 Conclusion: In conclusion, PRP alone provides better overall clinical improvement. We suggest that PRP should be considered as a monotherapy therapeutic option in the management of acne scars.
 Keywords: PRP, Scar, Acne
Highlights
Post acne scarring is a consequence of abnormal resolution or wound healing following the damage that occurs in the sebaceous follicle during acne inflammation.1 Scarring usually follows deep-seated inflammatory lesions, but may occur as a result of more superficial inflamed lesions in scar-prone patients
Background: Post acne scarring is a consequence of abnormal resolution or wound healing following the damage that occurs in the sebaceous follicle during acne inflammation Methods: Interventional split face comparative prospective study was conduct at Department of Dermatology, Venereology and Leprology, S N Medical College and Attached Hospitals, Jodhpur
We suggest that plateletrich plasma (PRP) should be considered as a monotherapy therapeutic option in the management of acne scars
Summary
Post acne scarring is a consequence of abnormal resolution or wound healing following the damage that occurs in the sebaceous follicle during acne inflammation. Scarring usually follows deep-seated inflammatory lesions, but may occur as a result of more superficial inflamed lesions in scar-prone patients. PRP is defined as plasma containing an above baseline concentration of platelets.. 6 Being an autologous preparation, PRP is devoid of any serious adverse effects. In our study we have adopted the centrifugation parameters used by Gonshor et al to obtain a desired platelet concentration of 4 – 7 times that of whole blood. It has been used in the management of acne scars as an adjuvant to other therapies such as ablative carbon dioxide fractional resurfacing, erbium fractional laser therapy and microneedling. It has been used in the management of acne scars as an adjuvant to other therapies such as ablative carbon dioxide fractional resurfacing, erbium fractional laser therapy and microneedling. 7 PRP seems to be a promising therapeutic modality but the level of evidence as of from the available published data is low
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