Abstract
Objectives: The objectives of the study were to study the effect of Morus alba leaves extract (MAE) on sleep by phenobarbitone-induced sleeping time and the antianxiety effect by elevated plus maze apparatus model in rats. Methods: In this study, the effect of MAE on sleep was evaluated by the phenobarbitone-induced sleeping time of rats. The onset and the duration of sleep were recorded in minutes. The antianxiety effect was evaluated by the elevated plus maze apparatus model in rats. During 5 min test period, the number of entries into the open arm and closed arm and time spent in the open arm and closed arm were recorded in seconds. Results: MAE at the dose 200 and 400 mg/kg, highly significantly (p<0.001) decreased the onset of phenobarbitone-induced sleeping time. The duration of sleeping time was increased significantly (p<0.01) for 200 mg/kg and highly significantly (p<0.001) for 400 mg/kg as compared to the control group. M. alba has significant antianxiety activity in comparison with control in a dose-dependent manner. M. alba in a dose of 200 mg showed significant (p<0.01) and 400 mg/kg treated groups showed highly significant (p<0.001) anxiolytic activity by increasing the mean time spent in open arms as compared to control but less significant with standard (diazepam). Conclusion: Results indicate that the MAE has a significant dose-dependent effect on phenobarbitone- induced sleeping time and antianxiety effect in the elevated plus maze test.
Highlights
India is one of the nations endowed with the inheritance of the traditional medicinal system
Morus alba leaves extract (MAE) group at 200 mg/kg and 400 mg/kg showed highly significant (p
MAE may act through gamma-aminobutyric acid (GABA) receptor complex or by decreasing dopaminergic transmission
Summary
India is one of the nations endowed with the inheritance of the traditional medicinal system. Herbal formulations are appraised as moderate in effectiveness and less toxic than most pharmaceutical agents [1]. Insomnia is difficulty in commencing or maintaining sleep. Insomnia statistics show a 1-year prevalence rate of 30–45% in adults [2]. Long-term utilization of commonly prescribed medications can lead to habituation and troublesome withdrawal symptoms. Herbal and other natural sleep aids are obtaining attention [3]
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