Abstract
Purpose To evaluate the retinal and choroidal thicknesses in patients with chronic obstructive pulmonary disease using optical coherence tomography. Methods The study included 26 patients with chronic obstructive pulmonary disease (COPD) and 26 age-matched healthy control groups. Detailed ocular examinations were performed on all participants. Cirrus EDI-OCT (enhanced depth imaging-optical coherence tomography) was used for choroidal thickness measurements with frame enhancement software. The subfoveal area was used for choroidal thickness measurements. Results The patients with the chronic obstructive pulmonary disease had an average 239.13 ± 57.77 μm subfoveal choroidal thickness, and the control group had an average 285.02 ± 25 μm subfoveal choroidal thickness. The subfoveal choroidal thickness measurements revealed a statistically significant difference between patients and the control group (p < 0.05). There were no statistically significant differences between patients and control group regarding mean macular thickness, central macular thickness, and GCIPL (ganglion cell-inner plexiform layer) thickness. Also, there was no statistically significant difference between patients and control group regarding mean, superior, nasal, inferior, and temporal RNFL (retinal nerve fiber layer) thicknesses. Conclusion Chronic hypoxemia seems to cause decreased choroidal thickness in patients with chronic obstructive pulmonary disease.
Highlights
Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and persistent respiratory symptoms due to airway and/or alveolar abnormalities which are caused by exposure to gases and deleterious particles. e disease is preventable and treatable [1]
Forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) ≤0.7 and forced expiratory volume in 1 second (FEV1) ≥80 confirms the presence of airflow limitation that is not fully reversible which should be done after using a bronchodilator [5]
To the best of our knowledge, this is the first study which revealed statistically significant difference between patients and control group regarding subfoveal choroidal thickness (SCT) in COPD patients and spectral domain optical coherence tomography (SD-OCT); a noninvasive test was used to measure choroidal thickness which has been believed to be the predictor of the healthy choroid [7, 8]
Summary
Received 2 March 2019; Revised 22 August 2019; Accepted 13 September 2019; Published 8 October 2019. To evaluate the retinal and choroidal thicknesses in patients with chronic obstructive pulmonary disease using optical coherence tomography. E study included 26 patients with chronic obstructive pulmonary disease (COPD) and 26 agematched healthy control groups. E patients with the chronic obstructive pulmonary disease had an average 239.13 ± 57.77 μm subfoveal choroidal thickness, and the control group had an average 285.02 ± 25 μm subfoveal choroidal thickness. E subfoveal choroidal thickness measurements revealed a statistically significant difference between patients and the control group (p < 0.05). Ere were no statistically significant differences between patients and control group regarding mean macular thickness, central macular thickness, and GCIPL (ganglion cell-inner plexiform layer) thickness. There was no statistically significant difference between patients and control group regarding mean, superior, nasal, inferior, and temporal RNFL (retinal nerve fiber layer) thicknesses. Chronic hypoxemia seems to cause decreased choroidal thickness in patients with chronic obstructive pulmonary disease
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