Abstract
OBJECTIVES: Several studies have established the functional markers that play role in human breast carcinomas and help the activities of anticancer agents. Although the treatment modalities of mammary carcinomas are chosen by evaluating prognostic parameters, none of the molecular markers has yet been accepted as an independent prognostic factor. However, recently, p53 tumour supressor gene and bcl-2 protooncogene have gained increasing interest. As well as estrogen receptor (ER) protein, progesterone receptor (PR) protein and c-erbB-2 levels are shown to have importance in individual response to hormonotherapy, radiotherapy and chemotherapy. Approaches of combining molecular markers provide more clinicopathological criteria that result in better predictions. In this study, we aimed to investigate the relationship of p53 and bcl-2 which are rather new markers, with c-erbB-2, ER and PR proteins. METHODS: In our pathology department, 65 mammary invasive ductal carcinoma cases are investigated for p53 and bcl-2, c-erbB-2, ER and PR expressions immunohistochemically (IHC) by using HRP-AEC methods. Besides, the staining percentages and staining intensity of the cases are compared statistically. RESULTS: Forty-seven out of 65 cases (72.3%) showed positive staining by p53, bcl-2 and PR protein. Forty-five out of 65 cases (69.2%) had positive staining by ER protein and 23 (35.3%) by c-erbB-2. Results were analysed by using chi square statistical analysis. There was no statistically significant correlation between p53 and bcl-2, c-erbB-2, ER or PR protein expressions (p>0.05) and between bcl-2 and c-erbB-2, ER or PR protein expressions (P>0.05). CONCLUSION: Although each one is accepted to have value regarding prognosis, our results, in acccordance with various literatures, did not show any statistically significant correlation between neither p53 nor bcl-2 and the selected prognostic parameters.
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