To Evaluate the Changes Arise in the Parameters of Liver and Kidney during Adjuvant Chemotherapy in Breast Cancer Patients

Abstract

To find out the variation in basic parameters of liver and kidney during FAC or CAF adjuvant chemotherapy in breast cancer patients at NIMRA jamshoro. A follow up study conducted at Nuclear, Institute of Medicine Radiotherapy (NIMRA), Jamshoro, Sindh, Pakistan. Our findings include the variations in the level of Total bilirubin, Alkaline phosphotae and Alanine transaminase as the parameters of liver. The mean±SD of total bilirubin before FAC (5-Fluorouracil, doxorubicin and cyclophosphamide) or CAF (Cyclophosphamide, doxorubicin and 5-Fluorouracil) Adjuvant Chemotherapy in Breast Cancer Patients was 0.76±0.23 and after it was 1.23±0.16. The mean±SD of Alkaline phosphatase before FAC or CAF Adjuvant Chemotherapy in Breast Cancer Patients was 96.2±2.89 and after it was 131±14.3 and Alanine tranaminase before FAC or CAF Adjuvant Chemotherapy the mean±SD was 25.5±6.18 and after it becomes 37.7±5.18. we found the variations in the level of urea and creatinine as the parameters of kidney. The mean±SD of urea and creatinine before FAC or CAF Adjuvant Chemotherapy in Breast Cancer Patients was 15.4±4.98 and 0.85±0.20 and after chemotherapy they were 28.0±1.70 and 1.76±0.09 respectively. The main parameters of liver and kidney were statistical signi cantly increased after the FAC or CAF adjuvant chemotherapy in the woman with breast cancer. These changes will alter the working of these organs put drastic effects on the normal metabolic and excretory function of liver and kidney.