To Evaluate Anti-HLA Antibodies Sensitization in Pre- and Post-renal Transplant Patient’s Serum: A Retrospective Case Series

Nishtha Agarwal,Sanjeev Goswami

doi:10.32892/jmri.187

Abstract

Introduction: In India, patients of renal failure are dependent on live related or unrelated donor. Because of poor financial condition patients do not go for DSA (Donor Specific Antibody) detection using Luminex. In absence of screening of de-novo production of DSA and don’t get proper management. As a result of which patient undergo acute rejection. Case Series: Here we are presenting 5 acute rejection cases comparing there DSA in pre-transplant and post-transplant sera using solid-phase assays.5 renal transplanted patients undergone acute and hyperacute rejection (Banff's classification) were considered for presented case series. Collected serum (pre and post-transplant on day of rejection) from each patient was subjected to detection of anti-HLA antibody using Luminex-PRA. Conclusion: Presence of donor-specific anti-HLA antibody with their titer was detected in pre and post-transplant serum. It is found that the strength of DSA is directly proportional to graft life.

Highlights

In India, patients of renal failure are dependent on live-related or unrelated donor
Many studies have shown that the presence of donor-specific anti-human leukocyte antibodies (HLAs) in patients is responsible for the graft survival
Studies conducted in case of other solid organ transplants had proved that the presence of anti-HLA antibody is responsible for the reduced graft life.[4]

Summary

Introduction

In India, patients of renal failure are dependent on live-related or unrelated donor. To Evaluate Anti-Human Leukocyte Antibodies Sensitization in Pre- and Post-renal Transplant Patient’s Serum: A Retrospective Case Series. Agarwal and Goswami: Anti-HLA antibodies and graft life after renal transplant five cases of renal transplant who underwent acute rejection. All five cases presented in this study are renal transplanted patients with live-related or unrelated donors and undergone graft rejection.

Results

Conclusion