Abstract
Background: Diabetes mellitus and cancer share common modifiable and non- modifiable risk factors. Both conditions have a great impact on social and economic status of an individual and their families. Diabetes is rapidly becoming a common metabolic problem in rural populations. At the same time, the incidence of oral cancer has not decreased over the years despite exhaustive research and has become the most common cause of death. Oral cancer accounts for approximately 4-5% of all cancers in the world. Recent epidemiological studies have shown a strong link between diabetes and cancer. Objective: To Estimate the concentration of Oxidative stress markers among Diabetic persons with Squamous cell carcinoma of oral cavity .Materials and Methods: A Case Control study, conducted at Sri Devaraj Urs Medical College attached to Sri R.L. Jalappa Hospital a constituent of Sri Devaraj Urs Academy of Higher Education and Research, Kolar. A total of 60 subjects were included in the study and categorised into equal number of cases and controls. Diabetic and lipid profiles were estimated by enzymatic methods in Dry chemistry Autoanalyser, Vitros 5.1FS, HbA1c analysed by HPLC (BioRad D10 USA), Nitric Oxide, Malondialdehyde, and Vitamin C by spectrophotometer Perkin Elmer UV/ VIS Lambda-35 methods respectively. Results: Our patients were in the age group of 30- 80 years with a mean age of 52.62± 12.67. Diabetic profile and oxidant markers were significantly elevated in cases compared to controls. However, mean values of lipid profile and antioxidants were significantly reduced in cases with an exception of LDL cholesterol, when comparing with controls Conclusion: Observations that has been made with lipid profile and antioxidant variables in diabetes with SCC was reduced might be due to their increased utilization by neoplastic cells for new membrane biogenesis. These findings strongly suggest, evaluation of these variables may help better patient care and build nation as well in addition to health education.
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