Abstract
Objective: To develop and validate a chromatographic method to determine the amount of drug (assay) in the tablets of memantine hydrochloride (MEM) using high performance liquid chromatography with refractive index (RI) detector. Methods: The chromatographic separation was achieved on C18 (250 × 4.5 mm, 5μ) column using isocratic mobile phase comprises of buffer (pH-6.0): Methanol (45:55 v/v) pumped at a flow rate of 1.0 ml/min. The detection of effluent was monitored using RI detector. Conclusion: The method was found to be simple, commercial, precise, accurate and robust which can be utilized for the determination of assay of MEM in tablets and capsules. Keywords: Memantine hydrochloride, Assay, Liquid chromatography, Refractive Index detector
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