Abstract
Background: In preemptive analgesia, the analgesic treatment is started before and is operational during the surgical procedure so that the physiological consequences of nociceptive transmission are reduced. Because of this protective effect on nociceptive pathways, preemptive analgesia decreases the incidence of hyperalgesia and allodynia after surgery.
 Methods: This Hospital based, prospective, randomized, double blind, comparative study was conducted in Department of Anaesthesiology, Sawai Man Singh Medical College after obtaining approval from Institutional Ethics Committee and Research Review Board and written informed consent from all the patients.
 Results: The mean baseline variable i.e. pulse rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were comparable in both the groups. (P value>0.05). Thus we can say that the randomization was done adequately. Hemodynamic variables (pulse rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure) were also comparable during intraoperative period.
 Conclusion: Although preemptive use of both pregabalin 75mg and pregabalin 150 mg are effective for prolongation of postoperative analgesia but pregabalin 75mg is superior to pregabalin 150mg as it provides similar postoperative analgesia as compared to 150mg without causing significant change in haemodynamic variables and any adverse effect.
 Keywords: Preemptive analgesia, Gabapentin, Rescue analgesic.
Highlights
At present, there are several drugs available that are being used as preemptive analgesics like local anesthetics, opioids, gabapentin, pregabalin, flupirtine, clonidine, NMDA receptor antagonists and their combination, in addition to nonsteroid anti-inflammatory drugs (NSAIDs) can be used to minimise postoperative pain.Pregabalin, is a structural analogue of the inhibitory neurotransmitter Gamma-Amino Butyric acid (GABA), but is functionally not related to it
The mean baseline variable i.e. pulse rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure were comparable in both the groups. (P value>0.05)
Conclusion: preemptive use of both pregabalin 75mg and pregabalin 150 mg are effective for prolongation of postoperative analgesia but pregabalin 75mg is superior to pregabalin 150mg as it provides similar postoperative analgesia as compared to 150mg without causing significant change in haemodynamic variables and any adverse effect
Summary
There are several drugs available that are being used as preemptive analgesics like local anesthetics, opioids, gabapentin, pregabalin, flupirtine, clonidine, NMDA receptor antagonists and their combination (multimodal), in addition to nonsteroid anti-inflammatory drugs (NSAIDs) can be used to minimise postoperative pain. Pregabalin, is a structural analogue of the inhibitory neurotransmitter Gamma-Amino Butyric acid (GABA), but is functionally not related to it. It was introduced in the treatment of epilepsy in 2004, useful in treating neuropathic pain as in diabetic neuropathy, post herpetic neuralgia and reflex sympathetic dystrophy. In view of the above observations, the present study was designed as prospective, randomized, doubleblind to compare the efficacy of different doses of pregabalin as preemptive analgesics in abdominal hysterectomy under spinal anaesthesia. Apoorva Magu et al, International Journal of Medical and Biomedical Studies (IJMBS)
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