Abstract
Dengue fever is a viral disease transmitted by infected mosquitoes, primarily Aedes aegypti and Aedes albopictus. Symptoms include fever, headache, joint and muscle pain, nausea, vomiting, and a rash. In severe cases, it can lead to complications such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), which can be fatal. The pathogenesis of dengue is a complex process involving viral replication, an immune response, and the potential for excessive inflammation and plasma leakage. Understanding the pathogenesis of dengue is crucial for the development of effective prevention and treatment strategies. Dengue virus is further divided into four distinct serotypes, known as DENV-1, DENV-2, DENV-3, and DENV-4, and infection with one serotype does not provide immunity against the other serotypes. There are currently no vaccines that can protect against all four serotypes of DENV.
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