Abstract
Cancer was initially considered a genetic disease. However, recent studies have revealed the connection between bacterial infections and growth of different types of cancer. The enteroinvasive strain of Mycoplasma hominis alters the normal behavior of host cells that may result in the growth of prostate cancer. The role of M. hominis in the growth and development of prostate cancer still remains unclear. The infection may regulate several factors that influence prostate cancer growth in susceptible individuals. The aim of this study was to predict M. hominis proteins targeted into the endoplasmic reticulum (ER) of the host cell, and their potential role in the induction of prostate cancer. From the whole proteome of M. hominis, 19 proteins were predicted to be targeted into the ER of host cells. The results of our study predict that several proteins of M. hominis may be targeted to the host cell ER, and possibly alter the normal pattern of protein folding. These predicted proteins can modify the normal function of the host cell. Thus, the intercellular infection of M. hominis in host cells may serve as a potential factor in prostate cancer etiology.
Highlights
Bacterial infection is recognized to play a significant role in the progression and advancement of various forms of cancers, including prostate, lung, gastric, and colon cancer [1,2,3]
We investigated the possible implication and relations of M. hominis proteome in the etiology of prostate cancer
Different M. hominis proteins in a particular host cell may change the usual functioning of the host cell and promote the process of growth and development of cancer. cNLS
Summary
Bacterial infection is recognized to play a significant role in the progression and advancement of various forms of cancers, including prostate, lung, gastric, and colon cancer [1,2,3]. Inflammation, and other factors are associated with the growth of prostate cancer, the exact mechanisms involved in growth of cancer due to bacterial infection are not very clear. Molecules 2018, 23, 994 are bacteria that lack cell walls, and are causative agents of various diseases related to respiratory and urogenital tract among humans [5,6]. The dominant types of mycoplasmas found in the urogenital system of humans include Mycoplasma genitalium, Ureaplasma urealyticum, and M. hominis. The relationship between mycoplasmas and the human population was first detected in the 1960s [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
