Abstract
Infectious Diseases| February 01 2004 To Decide if Clindamycin Is Optimal Drug for MRSA, Request a D-Test AAP Grand Rounds (2004) 11 (2): 18–19. https://doi.org/10.1542/gr.11-2-18 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation To Decide if Clindamycin Is Optimal Drug for MRSA, Request a D-Test. AAP Grand Rounds February 2004; 11 (2): 18–19. https://doi.org/10.1542/gr.11-2-18 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search nav search search input Search input auto suggest search filter All PublicationsAll JournalsAAP Grand RoundsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP NewsAll AAP Sites Search Advanced Search Topics: clindamycin, methicillin-resistant staphylococcus aureus Source: Siberry GK, Tekle T, Carroll K, et al. Failure of clindamycin treatment of methicillin-resistant Staphylococcus aureus expressing inducible clindamycin resistance in vitro. Clin Infect Dis. 2003;37:1257–1260. The increasing frequency of methicillin-resistant Staphylococcus aureus (MRSA) infections has led to renewed interest in clindamycin therapy for such infections.1 Some MRSA strains that are clindamycin-susceptible and erythromycin-resistant have inducible clindamycin resistance. There are 2 genes that cause erythromycin resistance in MRSA strains; one confers resistance to clindamycin and one does not. Differentiating between these 2 types of erythromycin resistance can be accomplished with a double disc diffusion assay or D-test. Investigators from Johns Hopkins University, Baltimore, Md, report a 5-year-old girl who failed clindamycin treatment for a clindamycin-sensitive, erythromycin-resistant MRSA surgical infection after craniosynostosis surgery. Following clindamycin treatment, MRSA genetically identical to the initial organism by pulse field gel electrophoresis, except for clindamycin resistance, was... You do not currently have access to this content.
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