Abstract
Cellular homeostasis requires protein remodeling mechanisms, such as microtubule severing, which is accomplished by enzymes that induce internal breaks in microtubules resulting in pruning or amplification of microtubule arrays. Severing enzymes belong to the AAA+ family. Their action is driven by ATP hydrolysis, leading to transitions between conformations of the oligomeric state of the machine. Structures for the oligomeric states, one in a spiral and the other in a ring arrangement, for two severing proteins have been solved leading to a proposed power stroke microtubule cutting mechanism.
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