To Compare the Pattern of Serum Non HDL, HDL Levels in Type 2 Diabetes Subjects With and Without Ischemic Heart Disease

Abstract

Individuals with DM may have several forms of dyslipidemia. Because of the additive cardiovascular risk of hyperglycemia and hyperlipidemia, lipid abnormalities should be assessed aggressively and treated as part of comprehensive diabetes care. The most common pattern of dyslipidemia is hypertriglyceridemia and reduced HDL cholesterol levels. DM itself does not increase levels of LDL, but the small dense LDL particles found in type 2 DM are more atherogenic because they are more easily glycated and susceptible to oxidation. Low HDL cholesterol as an independent risk factor for CHD Strong epidemiological evidence links low levels of serum HDL cholesterol to increased CHD morbidity and mortality. High HDL-cholesterol levels conversely convey reduced risk. Epidemiological data taken as a whole signify that a 1 percent decrease in HDL cholesterol is associated with a 2–3 percent increase in CHD risk. Epidemiological studies consistently show low HDL cholesterol to be an independent risk factor for CHD. Objective: To compare the pattern of serum non HDL, HDL levels in type 2 diabetes subjects with and without Ischemic Heart Disease. A descriptive study was carried out. Source of Data: Primary observed data of subjects with type 2 diabetes admitted to Medicine wards for ischemic heart disease. Control group of Type 2DM without IHD. Statistical Tests: Chi square test, students T test Bar and Pie chart. Related statistical techniques using SPSS version 21.0. Results: Among the 100 subjects chosen for the study, 59 subjects were males (59%) and remaining 41 subjects were females (41%). Majority of the subjects were in the age group of 50-69 years (60%). Mean non HDL value among non IHD was 67.1+14.6 and among IHD cases were at higher level i.e 176.4+18.7. p value showed statistical significance. Conclusion: UACR is statistically different among subjects with IHD compared to subjects without IHD. Hence subjects with Type 2 DM with IHD have been found to have higher total ....