Abstract
Fetal abnormality is a major cause of termination of pregnancy and preservation of the fetus is important for confirmation of the diagnosis. Various regimes have been reported for termination of pregnancy for fetal abnormality in the first and the second trimesters. In this paper, we compare those regimes that allow preservation of the fetus, in terms of the efficacy in expulsion of the fetus, the factors and the side effects.
Highlights
Fetal abnormality is known to be a major cause of perinatal mortality
The effects of gemeprost and mifepristone on the mechanical properties of the cervix prior to first trimester termination of pregnancy had been studied in the past it was shown that both were effective in increasing cervical distensibility
Termination of pregnancy for fetal abnormality in the first and second trimesters is feasible with those methods that are used for termination of pregnancy in general and yet preserving the fetus for pathological examination
Summary
Termination of pregnancy for fetal abnormalities significantly decreases perinatal mortality resulting from birth defects [1, 2]. Complete correlation between ultrasound findings and pathological examination is found in only 61.1% of autopsies. Pathological examination of fetal parts by use of radiography, gross dissection, microscopic examination, and/or cell culture for karyotyping or biochemical analysis may detect a major abnormality in 92%, and in 46% a specific diagnosis was obtained only from pathologic examination [6]. We compare the methods and outcome for termination of pregnancy for fetal abnormality in the first and second trimesters, respectively, especially those that potentially allow preservation of the fetus for pathological examination
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