To compare the hemodynamic effects of the infusion of both intravenous induction anaesthetic agents Etomidate and Propofol under bispectral index guidance

Abstract

Intravenous anaesthetic agents are preferred to induce anaesthesia in day to day practice because of rapid and smoother action with fewer risks. An ideal induction agent for general anaesthesia should have hemodynamic stability, minimal respiratory side effects and rapid clearance. This is a prospective, randomised, single blind, control study of total 60 patients.This study was carried out in Department of Anaesthesiology, at a Tertiary Care Teaching Hospital over a period of 1 year. In this study, a total of 60 patients undergoing elective surgery under general anaesthesia were randomized into two groups comprising of 30 patients in each group using envelop method. Group A- Patients received Inj. Etomidate infusion at the rate of 0.05 mg/kg/min through syringe infusion pump, and Group B – Patients received Inj. Propofol infusion at the rate of 0.5 mg/kg/min through syringe infusion pump.The hemodynamic response during induction of general Anaesthesia using Inj. Etomidate and Inj. Propofol under BIS guidance. There was no statistically significant difference observed in mean time taken for induction in both the groups. Mean consumed dose for Etomidate was 0.18+0.05 mg/kg and for Propofol group was 1.82+0.34 mg/kg. There was statistically significant fall in mean arterial blood pressure observed in Group B compared to Group A during and after induction up to 7 minutes. After that there was no significant difference observed in both the groups.: Propofol resulted in hypotension and bradycardia even with the reduced doses given with BIS- guided protocol. However, Etomidate provides more hemodynamic stability during induction and in post induction period also. So, Etomidate can be a better choice of agent for induction of General Anaesthesia as compared to Propofol.