To Compare the Efficacy of Two Intravenous Combinations of Drugs Ketamine-Propofol vs Ketamine-Dexmedetomidine for Sedation in Children Undergoing Dental Treatment.

Abstract

ObjectiveTo compare the efficacy of two intravenous combinations of drugs ketamine–propofol (KP) vs ketamine–dexmedetomidine (KD) for sedation in children undergoing dental treatment.Study designThirty patients were selected, evaluated according to the predetermined criteria and divided in equal numbers of 15 amongst 2 groups KP and KD.Materials and methodsInformed consent was taken, nil per oral (NPO) guidelines were followed and the study drug was administered. Dental procedure was performed. Heart rate (HR), blood pressure (BP) and oxygen saturation (SPO2) were monitored continuously throughout the procedure. The modified Ramsay sedation (MRS) score was recorded along with Houpt sedation score. Recovery status was accessed by modified Aldrete's recovery scale.Statistical analysisStudent t test was used for comparing HR, BP and SPO2. Chi-square test was used to compare MRS, Houpt sedation score and modified Aldrete's recovery scale amongst the two groups KP and KD.ResultsThe sedation achieved with both the groups was adequate. Both the drugs produce adequate hemodynamic stability.ConclusionKetamine–dexmedetomidine has a better efficacy over the other group, ketamine–propofol.How to cite this articleJoshi AB, Shankaranarayan UR, Hegde A, et al. To Compare the Efficacy of Two Intravenous Combinations of Drugs Ketamine–Propofol vs Ketamine–Dexmedetomidine for Sedation in Children Undergoing Dental Treatment. Int J Clin Pediatr Dent 2020;13(5):529–535.