Abstract
Helicobacter pylori eradication is the mainstay in the treatment of Helicobacter pylori associated peptic ulcer disease. Furazolidone was tried in several developing countries and showed good results in some trials. Increasing the duration of treatment has been shown to improve the eradication rate. This study was done to compare the efficacy of triple therapy for two weeks (Group-A) and three weeks (Group-B) consisting of omeprazole 20 mg b.d. amoxicillin 1 gm b.d. and furazolidone 200 mg b.d. in the eradication of Helicobacter pylori in duodenal ulcer patient. A total of 70 duodenal ulcer patients with Helicobacter pylori infection were included in the study. Healing of duodenal ulcer was assessed three months after the end of treatment and at the same time Helicobacter pylori eradication assessed by Campylobacter Like Organism (CLO) test and histology. In group-A, duodenal ulcer was healed in 17 (58.62%) patients and Helicobacter pylori was eradicated in 15 (52%) patients. In group-B, duodenal ulcer was healed in 19 (61.30%) patients and Helicobacter pylori was eradicated in 18 (58%) patients. Healing of duodenal ulcer was not significantly different between two groups. Eradication of Helicobacter pylori was also not significantly different between two groups.
Highlights
Duodenal ulcer disease is one of the most commonly encountered health problem in Bangladesh
Comparison between two groups showed no significant difference of Helicobacter pylori eradication (P= 0.622)
Antimicrobial treatment of Helicobacter pylori is difficult because of the habitat occupied by the organism below the layer of mucous adherent to gastric mucosa
Summary
Duodenal ulcer disease is one of the most commonly encountered health problem in Bangladesh. The prevalence of duodenal ulcer was estimated to be 11.98%1. Helicobacter pylori is widely prevalent in Bangladesh, with 60% of children being infected by the age 3 months and 80% being infected by the age of 3 years[3]. Successful treatment aiming at the cure of Helicobacter pylori infection results in the healing of duodenal ulcer disease and very low recurrence rate[5]. Several international consensus conference[6,7,8] recommended that all patients with duodenal or gastric ulcer who have Helicobacter pylori infection should receive anti Helicobacter pylori therapy to cure the infection. In most of the studies in Bangladesh, the eradication was between 30-64%11,12
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