Abstract
Background: Induction of labour is one of the most common obstetric interventions worldwide. The study was conducted to compare the efficacy and safety of 25µg (low dose) vaginal Misoprostol with intracervical Dinoprostone for cervical ripening and induction of labour in term pregnancy.
 Methods: For the purpose of this study, 100 term pregnancy patients (only primigravidae and second gravidae) were included who had spontaneous rupture of membrane before onset of labor. Data was collected from cases admitted in labor room at Pannadhay Mahila Chikitsalaya associated with RNT Medical College,Udaipur between July 2014 to July 2015.
 Results: Requirement of Oxytocin for augmentation of labor between group A and group B. It is evident from the table that oxytocin was required in only 16% of patients in group A, while 46% in group B. This indicates that requirement of oxytocin was significantly less in misoprostol group (P<0.001).
 Conclusion: This study was designed to assess efficacy of a 25 μg misoprostol vaginal tablet, Finding confirms that vaginal misoprostol tablet is as effective as dinoprostone in cervical ripening and labour induction with dinoprostone.
 Keywords: Cervical ripening, Dinoprostone, Labour induction, Low- dose misoprostol.
Highlights
Passage through birth canal is the shortest but probably the most hazardous journey made by any individual in his or her life
Data was collected from cases admitted in labor room at Pannadhay Mahila Chikitsalaya associated with RNT Medical College,Udaipur between July 2014 to July 2015
This indicates that requirement of oxytocin was significantly less in misoprostol group (P
Summary
Passage through birth canal is the shortest but probably the most hazardous journey made by any individual in his or her life. Induction of labour is the intentional initiation of labour for the purpose of delivery of the fetoplacental unit. It is carried out in 20% deliveries.[1] Oxytocin and prostaglandins are the main stay for labour induction. Cervical favorability is the prime determinant of success of labour induction and vaginal delivery. Misoprostol is a PGE1 analogue used through oral or vaginal route. It is used widely off label as an abortifacient and for labour induction. As compared to Dinoprostone, Misoprostol has certain decided advantages It is stable at room temperature, does not require special storage, is inexpensive, less invasive to use, has no bronchoconstrictor action and can be administered through several routes. Recent published studies have established that lower dosages of Misoprostol give similar or better results than PGE2, but with similar safety profile.[3]
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