Abstract
Objective: To determine the efficacy of prochlorperazine, cyclizine and ondansetron in patients following laparoscopic cholecystectomy, in terms of prevention of vomiting and nausea. Study Type: Randomized Control Trial. Duration and Location of Study: Anaesthesia department of the Bahawal Victoria Hospital, Bahawalpur over a period of January, 2018 to January, 2019. Methodology: Total of 324 patients divided into Group P, group O and group C received prochlorperazine (10mg), ondansetron (4mg) and cyclizine (50mg) respectively. Every patient was asked to tell when he/she is feeling nauseous, vomited and used additional antiemetic drugs. Descriptive data was compared by applying ANOVA test and Chi-square or Fischer’s exact test was applied on nominal data. Computer software SPSS version 23 was used to statistically analyze the data. P ≤0.05 was taken as significant., Results: Although occurrence of side effects was slightly higher in group-P, but all the groups were not statistically diffrent (p-value 0.581, 0.500 and 0.544 for headache, dizziness and sedation, respectively). Nausea and vomiting was observed in 4.6% in group-O patients, 5.5% in group-C patients and 8.3% in group-P patients, difference being statistically insignificant (p=0.500). , Conclusion: From the results of this study it can be concluded that all the three drugs i.e. cyclizine, ondansetron and prochlorperazine are equally effective and there is no statistically significant difference in terms of prevention of vomiting and nausea in patients undergoing cholecystectomy through laparoscope. Keywords: Ondansetron, Cyclizine, Prochlorperazine, postoperative nausea and vomiting DOI : 10.7176/JMPB/52-16
Highlights
Most common complaint is nausea and vomiting in patients within 24 to 48 hours following laparoscopic cholecystectomy and is called post-operative nausea and vomiting (PONV) 1
General anesthesia is associated with increased occurrence of PONV as compared to regional anesthesia 10
They divide the patients into 3 groups and give them ondansetron, prochlorperazine and cyclizine according to their groups to control vomiting and nausea
Summary
Most common complaint is nausea and vomiting in patients within 24 to 48 hours following laparoscopic cholecystectomy and is called post-operative nausea and vomiting (PONV) 1. We are studying the effects of PONV in patients who underwent laparoscopic cholecystectomy. Any intervention which decreases the incidence of postoperative nausea and vomiting in patients would be beneficial and in this way complications of PONV can be avoided. Ondansetron, cyclizine and prochlorperazine are the drugs which are used frequently in the avoidance of PONV in the patients who underwent laparoscopic cholecystectomy. In our study we are going to compare the effectiveness of these drugs for preventing vomiting and nausea after operation in people undergoing laparoscopic cholecystectomy. Usage of additional antiemetic drugs which are not part of this study for the avoidance of postoperative nausea and vomiting was taken into account.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
