Abstract
Objective:To compare anti-albumin urea effects of Valsartan alone with combination of Valsartan and Amlodipine in patients of chronic kidney disease.Methods:This randomized clinical trial was conducted at the Department of Medicine, Combined Military Hospital Bahawalpur, from April 2014 to 30 September 2014. 140 patients of chronic kidney disease with baseline blood pressure more than 140/90mm Hg having raised urinary albumin: creatinine ratio (UACR). UACR more than 3.5 mg/mmol was considered abnormal. Group-A was treated with Valsartan 80mg daily and Group-B was treated with valsartan 80 and amlodipine 10mg once a day. We did not change the dose of drugs and check spot UACR at base line and after six months with therapy and compare improvement in UACR between Group-A and B. Data was analyzed by statistical software packages (SPSS 16.0).Results:In both the groups, BP was significantly lower than the respective value. Mean decrease in spot UACR in Group-A was 3.18±2.64 mg/mmol and UACR in Group-B mean decrease in UACR was 13.01±20.11 mg/mmol. P value was< 0.05. Conclusion:The combination therapy of valsartan with amlodipine significantly lowers the albuminuria in chronic Kidney disease and reduce the progression of disease as compared to Valsartan alone therapy.
Highlights
Chronic kidney disease (CKD) is a heterogeneous group of disorders characterized by alterations in kidney structure and function, which manifests1
Group-A treated with Valsartan 80 mg once a day (ARBs) and Group-B treated with Valsartan 80 mg and Amlodipine 10 mg once a day(ARBs+calcium channel blockers (CCBs))
Paired t–test with in a group demonstrated there were significant reduction in albuminuria in both groups but patients in Group-B showed a marked reduction in albuminuria, with a mean difference of 13.01±2.11 mg/mmol, between pre and post treatment, which is statistically significant, p-value 0.001
Summary
Correspondence: December 9, 2015 April 25, 2016 May 4, 2016 as Glomerular filtration rate (GFR)
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