TO ASSESS SUBCLINICAL UREMIC ENCEPHALOPATHY IN NEWLY DIAGNOSED CHRONIC KIDNEY DISEASE PATIENTS BY USING ELECTROENCEPHALOGRAPHY IN TERTIARY CARE CENTRE

Abstract

Background: Chronic kidney disease(CKD) is one of the leading cause of death in the world because of its late or end stage presentation. In our study we assessed patients of CKD for cognitive dysfunction with EEG (electroencephalography) and other biochemical parameters. This cross-sectionalstudy was conducted on 60Methods: newly diagnosed CKDpatients at MGM Medical College and MY Hospital Indore, MP, India, from 2019 to 2021. Baseline parameters like serum urea, creatinine, bilirubin and sodium were done and patients were subjected to electroencephalography to assess subclinical uremic encephalopathy and data were analysed using SPSS statistics version 22.0 and p value <0.05 and condence interval more than 95% were considered signicant. In this study, beta wavesResults: were found to be maximum in stage1 (83.3%) whereas delta waves were found to be more in stage 5 (68%). In CKD stage 1, 16.7% patients had alpha waves and delta waves were absent. In CKD stage 5, 12% & 20% patients were having beta and alpha waves respectively. Epileptiform discharges were absent in patients of CKD stage 1 with stage 5 CKD having 80% patients with epileptiform discharges (P value =0.001). All patients in CKD stage1 have symmetrical EEG waves, with 80% asymmetrical waves were present in CKD stage 5 (P value=0.021). This study supports the fact that as CKDConclusions: stages progresses, there is propensity of delta waves, asymmetrical waves and epileptiform discharges which helps in early detection of subclinical uremic encephalopathy and therefore the risk of uremic seizures.