Abstract
Tumor necrosis factor (TNF) receptor–1 (TNF-R1) has several functions and has been a suspected player in the mechanisms of multiple sclerosis (MS). More than 20 years ago, TNF was shown to be toxic to oligodendrocytes,1 TNF was detected in active MS lesions at autopsy,2 and the CSF concentration of TNF was correlated with disease activity.3 These observations led to the hypothesis that TNF is a bad player in MS and its neutralization might be beneficial.
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