TNFAIP8L1 and FLT1 polymorphisms alter the susceptibility to cervical cancer amongst uyghur females in China

Lili Han,Mayinuer Niyazi,Chunhua Ma,Sulaiya Husaiyin,Lin Wang

doi:10.1042/bsr20191155

Lili Han, Mayinuer Niyazi + Show 3 more

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https://doi.org/10.1042/bsr20191155

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Abstract

TNFAIP8L1 and FLT1 play critical roles in the occurrence and development of tumors, but no in-depth studies have been carried out in cervical cancer. The present study aims to research the correlation between polymorphisms of these two genes and the risk of cervical cancer in the Uygur women. The study involved 342 cervical cancer patients and 498 healthy women. Five single nucleotide polymorphisms (SNPs) from the TNFAIP8L1 gene and the FLT1 gene were selected and genotyped. Odds ratio and 95% CIs were calculated by logistic regression analysis to evaluate the correlation between SNPs and cervical cancer risk. The alleles rs9917028-A (P=0.032), rs10426502-A (P=0.007), and rs1060555-G (P=0.026) of TNFAIP8L1 were associated with a decreased risk of cervical cancer. In the multiple genetic models, these three SNPs were also associated with the risk of cervical cancer. The stratified analysis showed that TNFAIP8L1-rs10426502, -rs1060555, and FLT1-rs9513111 were associated with a decreased risk of cervical cancer amongst people older than 43 years. Moreover, the haplotypes AG (P=0.007) and GC (P=0.026) of linkage disequilibrium block rs10426502|rs1060555 in TNFAIP8L1 were significantly associated with an increased risk of cervical cancer. Our results suggested that the relationships between TNFAIP8L1 and FLT1 polymorphisms and the risk of cervical cancer amongst Uyghur females.

Highlights

Cervical cancer is the third most common cancer amongst women worldwide, with 527,624 new cases and 265,672 deaths in 2012 [1]
In the present study, selected single nucleotide polymorphisms (SNPs) in TNFAIP8L1 and FLT1 and their association with cervical cancer risk were investigated for the first time
Three TNFAIP8L1 variants and one variant of FLT1 were associated with reduced cervical cancer susceptibility amongst females from Xinjiang Uyghur Autonomous Region of China

Summary

Introduction

Cervical cancer is the third most common cancer amongst women worldwide, with 527,624 new cases and 265,672 deaths in 2012 [1]. Much attention has been paid to the study of cervical cancer in Uygur women [4]. Etiological studies have shown that cervical cancer is the result of a combination of factors, including the high-risk human papillomavirus (HPV) infection, environmental, behavioral, and genetic factors [5,6]. In recent years, increasing evidence has emphasized the role of genetic factors in the pathogenesis of cervical cancer. Studies based on single nucleotide polymorphisms (SNPs) and genome-wide association studies have confirmed the relationship between genetic variations and the risk of cervical cancer in differenP-t populations [7,8,9]

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