Abstract
Impaired glucose regulation (IGR) is the prestate of diabetes; about 1/3 of IGR patients will develop to diabetes finally. In this study, we investigated the serum tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) levels in peripheral neuropathy impaired patients with impaired glucose regulation (IGR). A total of 70 IGR patients received the conventional nerve conduction test, including 30 patients with peripheral neuropathy (PN) and 40 patients without peripheral neuropathy (NPN). The other 40 healthy individuals were recruited as controls. The serum TNF-α and IL-6 in IGR patients were higher than in control group, and serum TNF-α and IL-6 levels in IGR-PN group were higher than in IGR-NPN group (27.7 ± 17.8 versus 13.1 ± 6.7 pg/mL and 18.1 ± 17.7 versus 6.4 ± 3.7 pg/mL, resp., both p < 0.05). Multifactors logistic regression analysis showed that TNF-α (OR = 0.893; p = 0.009) was an independent factor affecting whether IGR could combine with peripheral neuropathy. TNF-α and IL-6 could aggregate peripheral neuropathy in impaired glucose regulation patients; TNF-α might be independent risk factor for peripheral neuropathy in glucose regulation impaired patients.
Highlights
Abnormal glucose metabolism is one of the important reasons for the occurrence of peripheral neuropathy [1, 2]
The peripheral neuropathy was diagnosed according to the criteria of American Diabetes Association (ADA) in 2010 [12]; the clinical symptoms and signs and nerve conduction abnormalities in impaired glucose regulation (IGR)-PN group were in accordance with the diagnosis of distal symmetrical polyneuropathy
Whether impaired glucose regulation combined with peripheral neuropathy was considered as the dependent variable or the fasting blood glucose (FBG), OGTT2 h glucose, HbA1c, TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), CRP, IL-6, and TNF-α were considered as the independent variable for logistic regression analysis, the results showed that TNF-α (OR = 0.893; p = 0.009) was independent factor affecting whether impaired glucose regulation patient could have peripheral neuropathy
Summary
Abnormal glucose metabolism is one of the important reasons for the occurrence of peripheral neuropathy [1, 2]. Most impaired glucose regulation (IGR) patients will eventually develop to diabetes and the relationship between IGR and peripheral neuropathy is still controversial [4, 5]. A study showed that, based on the clinical symptoms results, 22% of diabetic patients and 23.9% of patients with abnormal glucose regulation of patients present distal symmetric multiple peripheral neuropathy [7]. These studies indicated that there were a large number of patients with diabetes and impaired glucose regulation who have peripheral neuropathy needed for early detection and intervention
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