Year-end Sale % OFF 
Abstract
BackgroundThe -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulgaris risk.MethodsWe searched in Pubmed, Embase, Web of Science and CNKI for studies evaluating the association between the -308 G/A gene polymorphism and acne vulgaris risk. Data were extracted and statistical analysis was performed using STATA 12.0 software.ResultsA total of five publications involving 1553 subjects (728 acne vulgaris cases and 825 controls) were included in this meta-analysis. Combined analysis revealed a significant association between this polymorphism and acne vulgaris risk under recessive model (OR = 2.73, 95% CI: 1.37–5.44, p = 0.004 for AA vs. AG + GG). Subgroup analysis by ethnicity showed that the acne vulgaris risk associated with the -308 G/A gene polymorphism was significantly elevated among Caucasians under recessive model (OR = 2.34, 95% CI: 1.13–4.86, p = 0.023).ConclusionThis meta-analysis suggests that the -308 G/A polymorphism in the TNF gene contributes to acne vulgaris risk, especially in Caucasian populations. Further studies among different ethnicity populations are needed to validate these findings.
Highlights
Acne vulgaris is a chronic inflammatory skin disease widely affecting adolescents and young adults [1]
Study Selection Studies were included in the meta-analysis if they satisfied the following inclusion criteria: (1) case-control studies focused on associations between tumor necrosis factor (TNF) gene -308 G/A polymorphisms and acne vulgaris risk; (2) genotype frequencies were available for cases and controls; (3) the distribution of genotypes in the control group was consistent with Hardy-Weinberg equilibrium (HWE). (4) when publications involved the overlapping data sets, only the study with the largest number of participants was included
A total of five publications evaluating the association between the TNF -308 G/A polymorphism and acne vulgaris risk were included in the meta-analysis, involving 1553 subjects (728 acne vulgaris cases and 825 controls) [12,13,14,15,16]
Summary
Acne vulgaris is a chronic inflammatory skin disease widely affecting adolescents and young adults [1]. Inflammation plays one of the main roles in the development of acne vulgaris [5,6]. Several single nucleotide polymorphisms (SNPs) in the TNF gene promoter have been identified [9,10], some of which may regulate TNF expression. One of these polymorphisms at position 308 (TNF -308 G/A) had been reported associated with regulation of TNF expression by, e.g., interfering with transcription factor binding sites or other regulatory elements [11]. The -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulgaris risk
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
