Abstract
This highlight summarizes a recent development of KF-promoted three-component fluorination-aminocarbonylation reaction of aldehydes, tertiary amines, and TMSCF2Br for the synthesis of structurally important α-fluoroamide derivatives. The key to the success of this method could be attributed to the multiple functions of difluorocarbene precursor (TMSCF2Br) as both a C1 synthon and a F1 reagent through the process of C–F bond cleavage and C–F bond re-formation.
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