Abstract
The frequencies of the TLR2 gene 2258G/A and the TLR4 gene 1196C/T and 896A/G polymorphisms in children with atopic dermatitis (AD) were studied against controls. It was established after analyzing the distribution of the TLR2 and TLR4 genotypes and alleles that the TLR4 geneβs mutant 896G allele is reliably more frequently detected in children with AD who are susceptible to acute respiratory viral infections (9.3%), compared to the control group (Ο2 = 4.33; p = 0.038). An analysis of the clinical manifestations of the disease and their associations has shown a higher frequency of its mild course (p = 0.0001) in children with AD who have normal body resistance and of a moderately severe course (p = 0.0033), as well as of concomitant allergic rhinitis (AR) and/or bronchial asthma (BA) (p = 0.0355) and concomitant AR (p = 0.0673), in AD patients with higher susceptibility to acute respiratory viral infections. A severe course of the disease (p = 0.0485), associated with adenoid vegetation in combination with AR and/or BA (p = n0.0248) and concomitant adenoid vegetation in combination with AR (p = 0.0053), was more frequent in AD patients with the TLR4 geneβs mutant 896G allele, compared to patients with a βwildβ-type allele.
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