Abstract
Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer.
Highlights
Cancer is associated with high morbidity and mortality rates
We focus on the mechanisms underlying the functions of TLE1 family proteins in pancreatic cancer
We focus on the roles of TLE1 in pancreatic cancer and explore targeted approaches for the treatment of this disease
Summary
Cancer is associated with high morbidity and mortality rates. It has a major impact on societies worldwide. We focus on the mechanisms underlying the functions of TLE1 family proteins in pancreatic cancer. TLE proteins can down-regulate the expression of transcriptional activators as well as enhance the effects of transcriptional repressors. TLEs can regulate the expression of genes that are targets of transcriptional activators, and can enhance the effects of transcriptional repressors.
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