Abstract
A new, simple and rapid thin-layer chromatographic method with densitometric detection has been developed and validated for analysis of oxaprozin and its degradation products. Chromatography was performed on silica gel plates with n -hexane-chloroform-glacial acetic acid 4:1:1 ( v/v ) as mobile phase. Densitometric analysis of oxaprozin was performed in absorbance mode at 286 nm. The method was validated for linearity, accuracy, and precision. Oxaprozin was subjected to acidic and alkaline hydrolysis. The degradation products were well resolved from the pure drug with significantly different R F values. LC-MS-MS analysis revealed that oxaprozin decomposes to produce 1,2-diphenylethanol, 4-iminobutanoic acid, and propan-1-imine.
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