Titration in nonaqueous solutions. XV. Direct differential potentiometric titration by glass-glass retarded electrodes. 1. Titration in anhydrous acetic acid.

Abstract

Direct differential potentiometric titrations in nonaqueous solutions were carried out using two glass electrodes, one of which is used as a retarded electrode. One and the greatest disadvantages of nonaqueous potentiometric titrations employing a reference electrode whose solvent is different from that of the solution or of the titrant, the fluctuation of liquid junction potentials between the two solutions of different solvents, can be overcome by this method. This method applied to the determinations of four derivatives of 1-phenyl-3-methyl-3-pyrazolin-5-one and several acid salts of diphenhydramine in anhydrous acetic acid solution with perchloric acid in acetic acid or p-dioxane as the titrant, was shown to give satisfactory and reproducible results.