Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up.

Mark K.C Van Goor,Jenny Van Der Wijst,Joost G.J Hoenderop

doi:10.1016/j.ceca.2022.102609

Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up.

Mark K.C Van Goor, Jenny Van Der Wijst + Show 1 more

https://doi.org/10.1016/j.ceca.2022.102609

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Journal: Cell calcium

Publication Date: May 31, 2022

Affiliation: Radboud Institute for Molecular Life Sciences

#PI P2 #Binding Of Phosphatidylinositol + Show 8 more

Abstract
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Abstract

TRPV5 is a highly selective calcium channel that finetunes urinary calcium excretion by reabsorbing calcium from the pro-urine. New structural findings show how PTH and pH control TRPV5 activity by altering the binding of endogenous ligands calmodulin and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

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