Abstract
AbstractThe titanocene(III) chloride (Cp2TiCl) mediated stereoselective synthesis of highly substituted tetrahydrofurans has been achieved by a reaction that proceeds through a tandem radical cyclization reaction between a Baylis–Hillman adduct and an activated bromo/iodo compound. The reaction of an epoxide with the Baylis–Hillman adduct furnished a spirolactone through a radical cyclization followed by an in situ lactonization. Cp2TiCl was prepared in situ from commercially available Cp2TiCl2and zinc dust in tetrahydrofuran.
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