Abstract
Enantioselective synthesis of two anti-tumor antibiotics, (−)-methylenolactocin and (−)-protolichesterinic acid, has been achieved through titanocene(III) chloride mediated radical cyclization reaction starting from commercially available d-mannitol. Titanocene(III) chloride (Cp 2TiCl) was prepared in situ from commercially available titanocene dichloride (Cp 2TiCl 2) and zinc dust in THF.
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