Titanocene Dichloride as an Efficient Catalyst for One-Pot Synthesis of α-Aminophosphonates

Abstract

Commercially available titanocene dichloride was firstly used as an extremely efficient catalyst for a three component one-pot reaction of an amine, an aldehyde (ketone), and a dialkyl phosphite to form α-aminophosphonates under solvent-free conditions at ambient temperature in good to high yields, providing a green, rapid and convenient method for the synthesis of α-aminophosphonates. Keywords: α-Aminophosphonates, multi-component reaction, titanocene dichloride, Aminophosphonates, titanocene, dichloride, multi-component reaction., antitumor agents, serine hydrolases, peptidomimetics, pharmacogenetical agents, enzyme, inhibitors