Abstract
While SN2 based desymmetrization of meso-epoxides has been extensively researched, the more general regioselective opening of cis-1,2 substituted epoxides via SN2 mechanism remains elusive. This short review outlines, how this limitation could be overcome by parting with SN2 and moving towards a radical-based mechanism. The development and refinement of the titanocene(III)-catalyzed regiodivergent epoxide opening (REO) is described.1 Introduction to Asymmetric Catalysis2 From Enantiodivergent to Regiodivergent Epoxide Opening3 Regiodivergent Arylation of Epoxides4 Conclusion
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