Abstract
The aim of this systematic review was to evaluate the effectiveness of titanium tetrafluoride as a preventive or cariostatic agent against caries. The databases used to find the articles analyzed were MEDLINE LILACS, and BBO. In MEDLINE and LILACS the search strategy utilized was "titanium" [Words] and "tetrafluoride" [Words] and Spanish or English or Portuguese [Language], whereas In BBO "titânio" [Words] and "tetrafluoreto" [Words] and Espanhol or Inglês or Português [Language]. Out of a total of 42 studies found, which assessed possible preventive/cariostatic effects of titanium tetrafluoride against caries in vivo, only 2 were selected. In both studies, titanium tetrafluoride was shown to be effective against caries. However, given that the quality and consequently the validity of these two clinical studies are questionable, their results do not allow to conclude that titanium tetrafluoride is effective against caries clinically.
Highlights
Fluorides are the most frequently used agents applied to the dental enamel surface to try to obtain greater resistance against caries
Internet research: articles from journals indexed in MEDLINE, LILACS (Latin American and Caribbean Literature on the Health Science) and BBO (Brazilian Bibliography of Dentistry) databases were accessed via BIREME (Latin American and Caribbean Center on Health Sciences Information – www.bireme.br)
Seventeen of the studies found in MEDLINE were carried out between 1993 and 2005 and 17 between 1966 and 1992, whereas in LILACS 3 studies were found and 9 in BBO
Summary
Fluorides are the most frequently used agents applied to the dental enamel surface to try to obtain greater resistance against caries Their effectiveness on patients with high caries activity has been put into question[8]. Several studies involving titanium tetrafluoride have been undertaken in an attempt to confirm its cariostatic properties. The findings of these studies reveal that when titanium tetrafluoride is applied to the dental enamel surface there is formation of fluoridated apatite, decreasing enamel solubility due to both an increase in the content of fluoride and formation of a film which protects the enamel against the action of acids[2,5,10]
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