Abstract
We measured plasma level of tissue type plasminogen activator (t-PA) antigen in patients with disseminated intravascular coagulation (DIC). Plasma levels of t-PA, PA inhibitor-1 (PAT-1), t-PA-PAI-1 complex, von Willebrand factor, thrombin-antithrombin III Complex (TAT), plasmin-α2 plasmin inhibitor complex (PIC), and FDP-D-dimer were markedly increased at the time of the onset of DIC but decreased after treatment. In most patients without leukemia, as the DIC score increased, plasma t-PA increased to 20 ng/ml or more. Plasma t-PA level before treatment for DIC was slightly higher in those showing poor outcome than it was in those showing good outcome. After treatment, t-PA level increased slightly in those showing poor outcome but decreased significantly in those showing good outcome. Plasma t-PA level was significantly higher in patients with organ failure than in those without. Positive correlation of plasma t-PA antigen level to PAI-1
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