Abstract
Purpose: The inadvertent damage to internal organs such as lungs and intestines after radiation therapy remains the major side effect and dose-limiting factor. This long-term damage usually appears as progressive fibrosis and tissue dysfunction. Transforming Growth Factor Beta 1 (TGF b1) has been shown to play a major role in development of fibrosis after irradiation. Tissue Transglutaminase (TG) is a cross-linking enzyme that stabilizes matrix by forming isopeptide covalent bonds between proteins making them resistant to proteolytical and mechanical damage. The purpose of this study was to investigate if TG mediates TGF b1 effects in radiation induced lung injury since TG is inducible by TGF b1 and activates TGF b1 from its latent state.
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