Abstract

Tissue specificity of gene expression sheds light on the tissue-selective manifestation of hereditary disease despite the same DNA across all tissues. The evolutionary path of such tissue specificity provides essential information about the tissue-specific function of genes and the validity of disease animal models. With recent improvements of the sequencing technology, more and more large-scale transcriptomics studies have been conducted among different species across multiple tissues. In this study, we exploit existing transcriptomics resources of humans, cynomolgus macaques, rats, mice, and dogs across 13 tissues. We find that although tissue specificity of homologous gene expression is largely well conserved across species, a total of 380 genes shift or are in the process of shifting their tissue specificity. The tissue-specificity-shifting genes are less conserved than those preserving their tissue specificity or housekeeping genes. Interestingly, tissue-specificity-shifting genes tend to be less conserved at the third codon positions, likely due to their relaxed synonymous codon usage bias. Moreover, compared with genes, cassette exons are more likely to shift their tissue specificity of splicing across the five species.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call