Abstract

Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes play critical roles in maturation and maintenance of vascular branching morphogenesis. In the central nervous system (CNS), pericytes are necessary for the formation and regulation of the blood-brain barrier (BBB) and pericyte deficiency accompanies CNS diseases including multiple sclerosis, diabetic retinopathy, neonatal intraventricular hemorrhage, and neurodegenerative disorders. Despite the importance of pericytes, their developmental origins and phenotypic diversity remain incompletely understood. Pericytes express multiple markers and the origin of pericytes differs by tissue, which may cause difficulty for the identification and understanding of the ontogeny of pericytes. Also, pericytes have the potential to give rise to different tissues in vitro but this is not clear in vivo. These studies indicate that pericytes are heterogeneous in a tissue- and context- dependent manner. This short review focuses on recent studies about identification of pericytes, heterogeneous origin of pericytes during development and in adults, and the differentiation capacity of pericytes, and pericytes in pathological settings.

Highlights

  • Pericytes are mural cells surrounding blood vessels and embedded within the basement membrane of the vasculature and adjacent to endothelial cells [1]

  • Recent studies have revealed that double PDGFRβEGFP and neural glial antigen 2 (NG2)-DsRed fluorescence reporter expression patterns are valuable for pericyte/mural cell identification of the central nervous system (CNS) tissues [24, 25]

  • We have recently revealed that myeloid progenitor cells differentiate into a subset of pericytes in the ectodermderived skin and brain during development (Figure 2) [26]

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Summary

Introduction

Pericytes are mural cells surrounding blood vessels and embedded within the basement membrane of the vasculature and adjacent to endothelial cells [1]. Recent studies have revealed that double PDGFRβEGFP and NG2-DsRed fluorescence reporter expression patterns are valuable for pericyte/mural cell identification of the CNS tissues [24, 25]. Chick-quail chimera analysis [35, 36] and genetic lineage tracing experiments using neural crest-specific Cre recombinase lines such as Wnt-1-Cre and Sox10-Cre mice in combination with a Cre-mediated reporter line demonstrate that neural crest contributes to pericytes in the face, brain, and thymus [36,37,38,39,40].

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